Tretinoin is intended for the treatment of acne. It allows controlling your acne, but does not cure it. The effects of tretinoin are based on promoting increased peeling of the skin areas affected by acne, which helps to unclog pores and prevent further formation of acne sores. Tretinoin is available as topical cream, gel and liquid.
This medicine should be applied once a day or once every 2-3 days, depending on the severity of your acne and the stage of your treatment. The condition of your acne may get worse during the first few days of the treatment, with your acne sores increasing and your skin reddening or scaling. This is normal and means the medicine is taking its effect. Your doctor will either recommend applying the selected form of tretinoin in the morning or at bedtime. It's important to follow the prescribed routine and apply the right amount for the medicine. You may need to be using tretinoin for a few months to achieve a visible effect. Even after that, you may require another course to maintain the effects.
As a topical drug, tretinoin is unlikely to interact with any oral drugs you may be taking. However, you should tell your pharmacist or doctor if you are already using any other topical creams or ointments to make sure these are not affected by tretinoin and do not affect its efficiency.
As with any other medicine, side effects are possible. The following side effects are reported by a small number of patients using tretinoin: red, scaling skin, increase in acne sores, mild stinging, lightening or darkening of the skin and swelling of the skin. If any of the mild side effects above do not go away as you keep using the medicine or become worse, you should contact a medical professional.
The medicine is applied once or twice daily to the skin. Dead cells are released from the cornea, so that the diseased skin can heal. Tretinoin stimulates cell renewal, prevents keratinization and infection of the sebaceous glands and inhibits the growth of tumor cells.
Before starting treatment, the physician tells the patient that the therapy is carried out over a long period of several weeks. After the first four weeks of treatment, the patient is asked to be monitored and, depending on the clinical effect and the side effects, are observed at longer intervals.
The pubertal acne, after a clinical cure, requires a preventative treatment for several months or even years before the disease completely disappears.
After the first eight to 14 days of treatment, there is a renewed apparent flare of the acne, which is due to an increased formation of blackheads with subsequent pustule formation. It is a so-called first aggravation, which occurs with many medicines.
It is the task of the physician to point the patient to this course during the initial call. For better compatibility, tretinoin is present in new carrier substances as polymers and microsponges. These reduce the irritation potential.
The drug is administered orally at a daily dose of 45 mg / m2 of body surface in 2 hours (for adults - about 8 capsules). For children it is recommended the same dose, unless there are severe toxic effects (in particular, the dose should be reduced, if a child appear intolerable headaches).
Treatment should be continued from 30 to 90 days until complete remission. Thereafter, immediately switch to a standard scheme of consolidation chemotherapy, such as three courses daunorubicin and cytosine arabinoside with an interval of 5-6 weeks.
To date, no cases of acute overdose described. Apparently, an accidental overdose of tretinoin will be shown reversible symptoms characteristic of hypervitaminosis A.
The dose recommended for patients with acute promyelocytic leukemia, is 1/4 of the dose, the maximum tolerated by patients with solid tumors, and is less than the maximum tolerated dose for children.
No specific treatment of overdose, it is important that the patient was admitted to the hematology department.
Attention! Please note that the interactions may vary depending on the dosage of a medicine (tablet, syringe, ointment).
Local use of tretinoin on the skin is advised against the use of other topical medicines, as skin reactions may be more violent. A long-term therapy with glucocorticoids can promote the emergence of mites (comedones) and should only be combined with a Tretinoin treatment of the skin for compelling reasons. In the case of UV or X-ray irradiation of the skin treated with Tretinoin, the skin-irritating effects intensify each other, so that increased redness and burning of the skin can be expected.
When tretinoin is used internally, the contraceptive effect of the "pill" may be reduced since tretinoin diminishes the effect of gestagens. Adequate protection against possible pregnancy must be ensured by additional, alternative methods of prevention.
Taking vitamin A or other active ingredients from the group of retinoids and the internal administration of tretinoin at the same time increases the unwanted drug effects. This can lead to symptoms of vitamin A overdose (nausea, vomiting, headache, skin dryness, mucosal dryness, skin redness, itching, bleeding, hair loss, bone pain, increased bone fracture, irritability). Therefore, the simultaneous use of these preparations should be avoided.
A systemic treatment with tretinoin can lead to a temporary increase in the cranial pressure (pseudotumor cerebri). Since antibiotics from the tetracycline group can also increase cranial pressure, patients should not be treated with tretinoin and tetracyclines simultaneously.
I reread and revised, probably hundreds of reviews about retinoids and brought out the optimal mode of using tretinoin, which I advise everyone (but ignore everyone, ha ha).
It is necessary to start with the lowest concentration of 0.025%. And no matter what you think about your skin. That it is insensitive, thick, porous. What you need to smear cream fatter and thicker. What you have long been using retinol or tretinoin generic. Think as you please, but start with the weakest option.
Apply Tretinoin only overnight. It collapses from sunlight, and some experts say that from electrical. Inflicted on the face - and sleep.
Tretinoin is applied only to dry skin. On thoroughly cleaned and very dry. Wash off cosmetics, wash and wait for 20-30 minutes (beginners) or 15 minutes (advanced users with adapted skin). No serum and creams should not be applied under tretinoin. If you can not tolerate dryness and peeling of the skin, then put tretinoin, waited another 15 minutes and put moisturizer. The effects of tretinoin will decrease. So if there is no need, then moisturizing is not necessary to apply.
Together with tretinoin, you must use AHA or BHA acid in your care. BHA (salicylic acid), if there is acne, black spots, increased sebum secretion. Or AHA (glycolic, lactic, malic, citric, tartaric, or a mixture thereof) if there are no acne.
Do not stop! This is a very important point of the program. The same is written in the instructions, but for some reason it is not applied to every tube. Continue to use the cream for 2-3 months, even if the skin is peeling off and the flow of acne has become aggravated, or acne has appeared, who has not had it before. It is not joke! Wait a little, and the result will please you. He is glad everyone who could endure an unpleasant period of adaptation.Lora 25 February, 2019